Publications – University of Copenhagen

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Publications from BRAINSTRUC Project Consortium

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Michael Lückmann, Mette Trauelsen, Marie A Bentsen, Tinne A D Nissen, Joao Martins, Zohreh Fallah, Mads M Nygaard, Elena Papaleo, Kresten Lindorff-Larsen, Thue W Schwartz and Thomas M Frimurer. (2019) Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1 Proceedings of the National Academy of Sciences of the United States of America 116(14):7123-7128.


Dennis Vestergaard Pedersen, Margot Revel, Trine Amalie Fogh Gadeberg and Gregers Rom Andersen. (2019) Crystallization and X-ray analysis of monodisperse human properdin Acta Crystallographica. Section F: Structural Biology and Crystallization Communications 75:2176-2187.


Alessandra Luchini, Achebe N. O. Nzulumike, Tania K. Lind, Tommy Nylander, Robert Barker, Lise Arleth, Kell Mortensen and Marite Cardenas. (2019) Towards biomimics of cell membranes Colloids and Surfaces B: Biointerfaces 173(3):202-209.


Amelie Stein, Douglas M. Fowler, Rasmus Hartmann-Petersen and Kresten Lindorff-Larsen. (2019) Biophysical and Mechanistic Models for Disease-Causing Protein Variants Trends in Biochemical Sciences 116(14):1-14.


Nicolai Tidemand Johansen, Frederik Grønbaek Tidemand, Tam T T N Nguyen, Kasper Dyrberg Rand, Martin Cramer Pedersen and Lise Arleth. (2019) Circularized and solubility-enhanced MSPs facilitate simple and high-yield production of stable nanodiscs for studies of membrane proteins in solution F E B S Journal 33(3):716-28.


Lene Clausen, Amanda Bering Abildgaard, Sarah K. Gersing, Amelie Stein, Kresten Lindorff-Larsen and Rasmus Hartmann-Petersen. (2019) Protein stability and degradation in health and disease Molecular Chaperones in Human Disorders 25(2):219-231.


Rasmus Scheller, Amelie Stein, Sofie V. Nielsen, Frederikke I. Marin, Anne-Marie Gerdes, Miriam Di Marco, Elena Papaleo, Kresten Lindorff-Larsen and Rasmus Hartmann-Petersen. (2019) Toward mechanistic models for genotype-phenotype correlations in phenylketonuria using protein stability calculations Human Mutation 40(4):444-457.


Sandro Bottaro, Giovanni Bussi, Giovanni Pinamonti, Sabine Reisser, Wouter Boomsma and Kresten Lindorff-Larsen. (2019) Barnaba RNA 25(2):219-231.


Thomas Skamris, Carlotta Marasini, Kenneth L. Madsen, Vito Foderà and Bente Vestergaard. (2019) Early Stage Alpha-Synuclein Amyloid Fibrils are Reservoirs of Membrane-Binding Species Scientific Reports 9:1-11.



Nicolai Tidemand Johansen, Martin Cramer Pedersen, Lionel Porcar, Anne Martel and Lise Arleth. (2018) Introducing SEC-SANS for studies of complex self-organized biological systems Acta crystallographica Section D: Structural biology 74:1178-1191.


Paula Szalai, Jan B. Parys, Geert Bultynck, Søren Brøgger Christensen, Poul Nissen, Jesper V. Møller and Nikolai Engedal. (2018) Nonlinear relationship between ER Ca2+ depletion versus induction of the unfolded protein response, autophagy inhibition, and cell death Cell Calcium 76:48-61.


Thomas Lykke Møller Sørensen, Samuel John Hjorth-Jensen, Esko Oksanen, Jacob Lauwring Andersen, Claus Olesen, Jesper Vuust Møller and Poul Nissen. (2018) Membrane-protein crystals for neutron diffraction Acta crystallographica Section D: Structural biology 74:1208-1218.


Andreas Haahr Larsen, Jerzy Dorosz, Thor Seneca Thorsen, Nicolai Tidemand Johansen, Tamim Darwish, Soren Roi Midtgaard, Lise Arleth and Jette Sandholm Kastrup. (2018) Small-angle neutron scattering studies on the AMPA receptor GluA2 in the resting, AMPA-bound and GYKI-53655-bound states IUCrJ 5:780-793.


Laure Yatime, Nicolas S. Merle, Annette G. Hansen, Niels Anton Friis, Jakob A. Østergaard, Mette Bjerre, Lubka T. Roumenina, Steffen Thiel, Peter Kristensen and Gregers R. Andersen. (2018) A single-domain antibody targeting complement component c5 acts as a selective inhibitor of the terminal pathway of the complement system and thus functionally mimicks the c-terminal domain of the staphylococcus aureusSSL7 protein Frontiers in Immunology 9:2176-2187.


Jacob Lauwring Andersen, Borbala Gesser, Erik Daa Funder, Christine Juul Fælled Nielsen, Helle Gotfred-Rasmussen, Mads Kirchheiner Rasmussen, Rachel Toth, Kurt Vesterager Gothelf, J. Simon C. Arthur, Lars Iversen and Poul Nissen. (2018) Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases Nature Communications 9(1):48-61.


Nicholas Skar-Gislinge, Nicolai Tidemand Johansen, Rasmus Hoiberg-Nielsen and Lise Arleth. (2018) Comprehensive Study of the Self-Assembly of Phospholipid Nanodiscs Langmuir 34(42):12569-12582.


Andreas Haahr Larsen, Lise Arleth and Steen Hansen. (2018) Analysis of small-angle scattering data using model fitting and Bayesian regularization Journal of Applied Crystallography 51:1151-1161.


Gregory Smith, Erik Brok, Grethe Vestergaard Jensen, Soren Roi Midtgaard, Nicholas Skar-Gislinge and Lise Arleth. (2018) Casein studied by X-ray and neutron scattering ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256(42):12569-12582.


Gregory Smith, Erik Brok, Martin Schmiele, Lise Arleth and Kell Mortensen. (2018) LINX ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256(42):12569-12582.


Gregory Smith, Erik Brok, Martin Schmiele, Lise Arleth, Kell Mortensen, Martin Alm and Peter Thomsen. (2018) Small-angle scattering of interpenetrating polymer networks (IPNs) as medical devices with reduced risk of infection ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256(42):12569-12582.


Joao Henriques, Lise Arleth, Kresten Lindorff-Larsen and Marie Skepo. (2018) On the Calculation of SAXS Profiles of Folded and Intrinsically Disordered Proteins from Computer Simulations Journal of Molecular Biology 430:2521-2539.


Henriette E. Autzen, Heidi Koldsø, Phillip J. Stansfeld, Pontus Gourdon, Mark S.P. Sansom and Poul Nissen. (2018) Interactions of a Bacterial Cu(I)-ATPase with a Complex Lipid Environment Biochemistry 57(28):4063-4073.


Rasmus K Jensen, Rasmus Pihl, Trine A F Gadeberg, Jan K Jensen, Kasper R Andersen, Steffen Thiel, Nick S Laursen and Gregers Rom Andersen. (2018) A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement Journal of Biological Chemistry 293(17):6269-6281.


Simon A Mortensen, Bjørn Sander, Rasmus K Jensen, Jan S Pedersen, Monika M Golas, Steffen Thiel and Gregers R Andersen. (2018) Models of the complement C1 complex Proceedings of the National Academy of Sciences of the United States of America 115(17):6269-6281.


Muwan Chen, Sofie H. Laursen, Mette Habekost, Camilla H. Knudsen, Susanne H. Buchholdt, Jinrong Huang, Fengping Xu, Xin Liu, Lars Bolund, Yonglun Luo, Poul Nissen, Fabia Febbraro and Mark Denham. (2018) Central and peripheral nervous system progenitors derived from human pluripotent stem cells reveal a unique temporal and cell-type specific expression of PMCAs Frontiers in Cell and Developmental Biology 6(28):4063-4073.


Tone Bengtsen, Viktor Lindahl Holm, Søren Roi Midtgaard, Lise Arleth and Kresten Lindorff-Larsen. (2018) A Combined Simulation and SAXS Study of the Dynamics of Lipid Nanodiscs Biophysical Journal 114:559A-559A.


Frederic Jabs, Melanie Plum, Nick Stub Laursen, Rasmus Kjeldsen Jensen, Brian Mølgaard, Michaela Miehe, Marco Mandolesi, Michéle M. Rauber, Wolfgang Pfützner, Thilo Jakob, Christian Möbs, Gregers Rom Andersen and Edzard Spillner. (2018) Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FceRI interaction Nature Communications 9(1):6269-6281.


Elena Papaleo, Carlo Camilloni, Kaare Teilum, Michele Vendruscolo and Kresten Lindorff-Larsen. (2018) Molecular dynamics ensemble refinement of the heterogeneous native state of NCBD using chemical shifts and NOEs PeerJ 6(5):1-24.


Jill J. Bouchard, Joel H. Otero, Daniel C. Scott, Elzbieta Szulc, Erik W. Martin, Nafiseh Sabri, Daniele Granata, Melissa R. Marzahn, Kresten Lindorff-Larsen, Xavier Salvatella, Brenda A. Schulman and Tanja Mittag. (2018) Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments Molecular Cell 72(1):19-36, e1-e8.


Katharina Weinhaupl, Caroline Lindau, Audrey Hessel, Yong Wang, Conny Schültze, Tobias Jores, Laura Melchionda, Birgit Schönfisch, Hubert Kalbacher, Beate Bersch, Doron Rapaport, Martha Brennich, Kresten Lindorff-Larsen, Nils Wiedemann and Paul Schanda. (2018) Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space Cell 175(5):1365-1379, e25.


Maher M. Kassem, Lars B. Christoffersen, Andrea Cavalli and Kresten Lindorff-Larsen. (2018) Enhancing coevolution-based contact prediction by imposing structural self-consistency of the contacts Scientific Reports 8(5):74-82.


Mustapha Carab Hussein Ahmed, Elena Papaleo and Kresten Lindorff-Larsen. (2018) How well do force fields capture the strength of salt bridges in proteins? PeerJ 6(1):19-36, e1-e8.


Paul Santner, Joao Miguel da Silva Martins, Caroline Kampmeyer, Rasmus Hartmann-Petersen, Jonas S. Laursen, Amelie Stein, Christian A Olsen, Isaiah T Arkin, Jakob R. Winther, Martin Willemoës and Kresten Lindorff-Larsen. (2018) Random mutagenesis analysis of the Influenza A M2 proton channel reveals novel resistance mutants Biochemistry 57(41):5957-5968.


Pavel V. Shliaha, Sebastian Gibb, Vladimir Gorshkov, Malena Schack Jespersen, Gregers R. Andersen, Derek Bailey, Jacob Schwartz, Shannon Eliuk, Veit Schwämmle and Ole N. Jensen. (2018) Maximizing Sequence Coverage in Top-Down Proteomics by Automated Multimodal Gas-Phase Protein Fragmentation Analytical Chemistry 90(21):12519-12526.


Robert B. Best and Kresten Lindorff-Larsen. (2018) Editorial overview: Theory and simulation: Interpreting experimental data at the molecular level Current Opinion in Structural Biology 49(5):iv-v.


Sandro Bottaro and Kresten Lindorff-Larsen. (2018) Biophysical experiments and biomolecular simulations Science 361(6400):355-360.


Sandro Bottaro, Giovanni Bussi, Scott D. Kennedy, Douglas H. Turner and Kresten Lindorff-Larsen. (2018) Conformational ensembles of RNA oligonucleotides from integrating NMR and molecular simulations Science Advances 4(5):19-36, e1-e8.


Saskia Bucciarelli, Søren Roi Midtgaard, Martin Nors Pedersen, Søren Skou, Lise Arleth and Bente Vestergaard. (2018) Size-exclusion chromatography small-angle X-ray scattering of water soluble proteins on a laboratory instrument Journal of Applied Crystallography 51(6):1623-1632.


Søren Roi Midtgaard, Tamim A Darwish, Martin Cramer Pedersen, Pie Huda, Andreas Haahr Larsen, Grethe Vestergaard Jensen, Søren Andreas Røssell Kynde, Nicholas Skar-Gislinge, Agnieszka Janina Zygadlo Nielsen, Claus Olesen, Mickael Blaise, Jerzy Jòzef Dorosz, Thor Seneca Thorsen, Raminta Venskutonyte, Christian Krintel, Jesper V. Møller, Henrich Frielinghaus, Elliot Paul Gilbert, Anne Martel, Jette Sandholm Jensen Kastrup, Poul Erik Jensen, Poul Nissen and Lise Arleth. (2018) Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering F E B S Journal 285(2):357-371.


Yong Wang, Katrine Østergaard Bugge, Birthe Brandt Kragelund and Kresten Lindorff-Larsen. (2018) Role of protein dynamics in transmembrane receptor signalling Current Opinion in Structural Biology 48(5):74-82.


Yong Wang, Omar Valsson, Pratyush Tiwary, Michele Parrinello and Kresten Lindorff-Larsen. (2018) Frequency adaptive metadynamics for the calculation of rare-event kinetics Journal of Chemical Physics 149(7):1-7.



Caroline Kampmeyer, Sofie V. Nielsen, Lene Clausen, Amelie Stein, Anne-Marie Axø Gerdes, Kresten Lindorff-Larsen and Rasmus Hartmann-Petersen. (2017) Blocking protein quality control to counter hereditary cancers Genes, Chromosomes & Cancer 56(12):823-831.


Pankaj Sehgal, Paula Szalai, Claus Olesen, Helle A Praetorius, Poul Nissen, Søren Brøgger Christensen, Nikolai Engedal and Jesper Vuust Møller. (2017) Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response Journal of Biological Chemistry 292(2):19656-19673.


Mateusz Dyla, Daniel Terry, Magnus Kjærgaard, Thomas Lykke-Møller Sørensen, Jacob Lauwring Andersen, Jens Peter Andersen, Charlotte Rohde Knudsen, Roger Altman, Poul Nissen and Scott Blanchard. (2017) Dynamics of P-type ATPase transport cycle revealed by single-molecule FRET Nature 551(7680):346-351.


Dennis V. Pedersen, Lubka Roumenina, Rasmus K. Jensen, Trine A. F. Gadeberg, Chiara Marinozzi, Capucine Picard, Tania Rybkine, Steffen Thiele, Uffe B. S. Sorensen, Cordula Stover, Veronique Fremeaux-Bacchi and Gregers R. Andersen. (2017) Structural and functional studies of human complement factor P Molecular Immunology 89:197-198.


Rasmus Kjeldsen Jensen, Rasmus Pihl, Nick Stub Laursen, Steffen Thiel and Gregers Rom Andersen. (2017) A novel nanobody inhibitor of the alternative pathway Molecular Immunology 89(21):198.


Ruth Hendus-Altenburger, Matteo Lambrughi, Thilde Bagger Terkelsen, Stine Helene Falsig Pedersen, Elena Papaleo, Kresten Lindorff-Larsen and Birthe Brandt Kragelund. (2017) A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1) Cellular Signalling 37(9):40-51.


Thomas Jank, Yury Belyi, Christophe Wirth, Sabine Rospert, Zehan Hu, Joern Dengjel, Tina Tzivelekidis, Gregers Rom Andersen, Carola Hunte, Andreas Schlosser and Klaus Aktories. (2017) Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A Journal of Biological Chemistry 292(21):16014-16023.


Trine A. F. Gadeberg, Dennis Vestergaard Pedersen and Gregers Rom Andersen. (2017) Structural studies of convertases in the complement system. The properdin-stabilised proconvertase, and the C5 convertase Molecular Immunology 89:198.


Yong Wang, João Martins and Kresten Lindorff-Larsen. (2017) Biomolecular conformational changes and ligand binding Chemical Science 8(9):6466-6473.


F. Jabs, M. Plum, N. S. Laursen, R. Jensen, M. Miehe, C. Moebs, W. Pfuetzner, T. Jakob, G. R. Andersen and E. Spillner. (2017) An anti-IgE single domain antibody disrupts the interaction of IgE with fceri by acting as functional high affinity mimic of cd23 Allergy: European Journal of Allergy and Clinical Immunology 72:13-13.


Mads Nygaard, Birthe Brandt Kragelund, Elena Papaleo and Kresten Lindorff-Larsen. (2017) An efficient method for estimating the hydrodynamic radius of disordered protein conformations Biophysical Journal 113(3):550-557.


Sandro Bottaro and Kresten Lindorff-Larsen. (2017) Mapping the universe of RNA tetraloop folds Biophysical Journal 113(2):257-267.


Simon A Mortensen, Bjørn Sander, Rasmus Kjeldsen Jensen, Jan S Pedersen, Monika Golas, Jens C Jensenius, Annette G Hansen, Steffen Thiel and Gregers R Andersen. (2017) Reply to Arlaud et al. Proceedings of the National Academy of Sciences of the United States of America 114(29):E5768-E5770.


Sofie V, Nielsen, Amelie Stein, Alexander B. Dinitzen, Elena Papaleo, Michael H. Tatham, Esben Guldahl Poulsen, Maher Mahmoud Kassem, Lene Juel Rasmussen, Kresten Lindorff-Larsen and Rasmus Hartmann-Petersen. (2017) Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations PLoS Genetics 13(4):257-267.


Tina Skjørringe, Per Amstrup Pedersen, Sidsel Salling Thorborg, Poul Nissen, Pontus Gourdon and Lisbeth Birk Møller. (2017) Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease Scientific Reports 7(1):346-351.


Thu Phuong Tran, Christian Ørnbøl Larsen, Tobias Røndbjerg, Martina de Foresta, Micha Ben Achim Kunze, Ales Marek, Jacob Hartvig Løper, Lotte-Emilie Boyhus, Astrid Knuhtsen, Kresten Lindorff-Larsen and Daniel Sejer Pedersen. (2017) Diversity-oriented peptide stapling Chemistry: A European Journal 23(14):3490-3495.


Meng S. Choy, Yang Li, Luciana E. S. F. Machado, Micha Ben Achim Kunze, Christopher R. Connors, Xingyu Wei, Kresten Lindorff-Larsen, Rebecca Page and Wolfgang Peti. (2017) Conformational rigidity and protein dynamics at distinct timescales regulate PTP1B activity and allostery Molecular Cell 65(4):644-658.


Isabel Fatima Herranz Trillo, Minna Grønning Jensen, Andreas van Maarschalkerweerd, Romà Tauler, Bente Vestergaard and Pau Bernadó. (2017) Structural Analysis of Multi-component Amyloid Systems by Chemometric SAXS Data Decomposition Structure 25(1):5–15.


Simon A Mortensen, Bjoern Sander, Rasmus K Jensen, Jan Skov Pedersen, Monika M Golas, Jens C Jensenius, Annette G Hansen, Steffen Thiel and Gregers R Andersen. (2017) Structure and activation of C1, the complex initiating the classical pathway of the complement cascade Proceedings of the National Academy of Sciences of the United States of America 114(5):986-991.


Carlotta Marasini and Bente Vestergaard. (2017) SAS-Based Studies of Protein Fibrillation Biological Small Angle Scattering: Techniques, Strategies and Tips 25(1):5–15.


Carlotta Marasini, Vito Foderà and Bente Vestergaard. (2017) Sucrose modulates insulin amyloid-like fibril formation: effect on the aggregation mechanism and fibril morphology RSC Advances 7(1):10487-10493.


Dennis V Pedersen, Lubka T Roumenina, Rasmus K Jensen, Trine Af Gadeberg, Chiara Marinozzi, Capucine Picard, Tania Rybkine, Steffen Thiel, Uffe Bs Sørensen, Cordula Stover, Veronique Fremeaux-Bacchi and Gregers R Andersen. (2017) Functional and structural insight into properdin control of complement alternative pathway amplification E M B O Journal 36(8):986-991.


Dorota Focht, Tristan Ian Croll, Bjorn P Pedersen and Poul Nissen. (2017) Improved Model of Proton Pump Crystal Structure Obtained by Interactive Molecular Dynamics Flexible Fitting Expands the Mechanistic Model for Proton Translocation in P-Type ATPases Frontiers in Physiology 8(1):346-351.


Hassina Azouaoui, Cedric Montigny, Thibaud Dieudonné, Philippe Champeil, Aurore Jacquot, José Luis Vázquez-Ibar, Pierre le Maréchal, Jakob Ulstrup, Miriam-Rose Ash, Joseph A Lyons, Poul Nissen and Guillaume Lenoir. (2017) A High and Phosphatidylinositol-4-phosphate (PI4P)-dependent ATPase Activity for the Drs2p/Cdc50p Flippase after Removal of its N- and C-terminal Extensions Journal of Biological Chemistry 292(1):7954-7970.


Helena Steinocher, Katrine Østergaard Bugge, Louise Fletcher Nikolajsen, Kresten Lindorff-Larsen, Andrew Brooks and Birthe Brandt Kragelund. (2017) Class I Cytokine Receptors Biophysical Society. Annual Meeting. Abstracts 112:171A.


Joseph A. Lyons, Andreas Bøggild, Poul Nissen and Jens Frauenfeld. (2017) Saposin-Lipoprotein Scaffolds for Structure Determination of Membrane Transporters Methods in Enzymology 8(1):346-351.


Sebastian Stolzenberg, Zheng Li, Matthias Quick, Lina Malinauskaite, Poul Nissen, Harel Weinstein, Jonathan A Javitch and Lei Shi. (2017) The Role of TM5 in Na2 Release and the Conformational Transition of Neurotransmitter:Sodium Symporters toward the Inward-Open State Journal of Biological Chemistry 292(1):346-351.


Simon Boje Hansen, Nick Stub Laursen, Gregers Rom Andersen and Kasper R Andersen. (2017) Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures Acta crystallographica Section D: Structural biology 73:804-813.


Yangzi He, Jonathan P Staley, Gregers Rom Andersen and Klaus H Nielsen. (2017) Structure of DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA RNA 23(8):1110-1124.



Katrine Østergaard Bugge, Kresten Lindorff-Larsen and Birthe Brandt Kragelund. (2016) Understanding single-pass transmembrane receptor signaling from a structural viewpoint—what are we missing? The F E B S Journal 283(24):4424-4451.


Laure Yatime, Cristine Betzer, Rasmus Kjeldsen Jensen, Sofia Mortensen, Poul Henning Jensen and Gregers Rom Andersen. (2016) The Structure of the RAGE:S100A6 Complex Reveals a Unique Mode of Homodimerization for S100 Proteins Structure 24(12):2043-2052.


Aghiad Ghazal, Josiane P Lafleur, Kell Mortensen, Jörg P Kutter, Lise Arleth and Grethe V Jensen. (2016) Recent advances in X-ray compatible microfluidics for applications in soft materials and life sciences Lab On a Chip 16(22):4263-4295.


Janus A Schatz-Jakobsen, Dennis V Pedersen and Gregers R Andersen. (2016) Structural insight into proteolytic activation and regulation of the complement system Immunological Reviews 274(1):59-73.


Maria Giovanna Di Carlo, Valeria Vetri, Gianpiero Buscarino, Maurizio Leone, Bente Vestergaard and Vito Foderà. (2016) Trifluoroethanol modulates a-synuclein amyloid-like aggregate formation, stability and dissolution Biophysical Chemistry 216(1):23-30.


Tristan Ian Croll and Gregers Rom Andersen. (2016) Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF) Acta crystallographica Section D: Structural biology 72(9):1006-1016.


Bente Vestergaard. (2016) Analysis of biostructural changes, dynamics, and interactions - Small-angle X-ray scattering to the rescue Archives of Biochemistry and Biophysics 602(1):69-79.


Eva Stephanie Lobbens, Leonid Breydo, Thomas Skamris Pedersen, Bente Vestergaard, Anna K Jäger, Lene Jørgensen, Vladimir Uversky and Marco van de Weert. (2016) Mechanistic study of the inhibitory activity of Geum urbanum extract against a-Synuclein fibrillation B B A - Proteins and Proteomics 1864(9):1160-1169.


Joseph A Lyons, Azadeh Shahsavar, Peter Aasted Paulsen, Bjørn Panyella Pedersen and Poul Nissen. (2016) Expression strategies for structural studies of eukaryotic membrane proteins Current Opinion in Structural Biology 38(1):137-144.


Maria Risager Jensen, Goran Bajic, Xianwei Zhang, Anne Kjær Laustsen, Heidi Koldsø, Katrine Kirkeby Skeby, Birgit Schiøtt, Gregers R Andersen and Thomas Vorup-Jensen. (2016) Structural basis for simvastatin competitive antagonism of complement receptor 3 Journal of Biological Chemistry 72(9):1006-1016.


Sofia Mortensen, Jan Kristian Jensen and Gregers Rom Andersen. (2016) Solution Structures of Complement C2 and its C4 Complexes Propose Pathway Specific Mechanisms for Control and Activation of the Complement Proconvertases Journal of Biological Chemistry 291(32):16494-16507.


Janus Asbjørn Schatz-Jakobsen, yuchun zhang, Krista Johnson, Alyssa Neill, Douglas Sheridan and Gregers Rom Andersen. (2016) Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway Journal of Immunology 197(1):337-344.


Johannes D. Clausen, Maike Bublitz, Bertrand Jean-Paul Arnou, Claus Olesen, Jens Peter Andersen, Jesper Vuust Møller and Poul Nissen. (2016) Crystal Structure of the Vanadate-Inhibited Ca2+-ATPase Structure 24(4):617-623.


Jonas Lindholt, Daniel Mattle, Natalya Fedosova, Poul Nissen and Linda Schuldt. (2016) Isolation, crystallization and crystal structure determination of bovine kidney Na+,K+-ATPase Acta Crystallographica. Section F: Structural Biology and Crystallization Communications 72:282-287.


Stéphanie David-Bosne, Michael Voldsgaard Clausen, Hanne Poulsen, Jesper Vuust Møller, Poul Nissen and Marc Le Maire. (2016) Erratum Nature Structural and Molecular Biology 23(4):617-623.


Andreas Kirscht, Shreyas S Kaptan, Gerd Patrick Bienert, François Chaumont, Poul Nissen, Bert L de Groot, Per Kjellbom, Pontus Gourdon and Urban Johanson. (2016) Crystal Structure of an Ammonia-Permeable Aquaporin PLoS Biology 14(3):e1002411.


Bjørn Panyella Pedersen, Pontus Gourdon, Xiangyu Liu, Jesper Lykkegaard Karlsen and Poul Nissen. (2016) Initiating heavy-atom-based phasing by multi-dimensional molecular replacement Acta crystallographica Section D: Structural biology 72:440-445.


Rune Thomas Kidmose and Gregers Rom Andersen. (2016) Interacting with the Human Insulin Receptor Structure 24(3):351-352.


Thomas Skamris Pedersen, Xinsheng Tian, Matthias Thorolfsson, Hanne Sophie Karkov, Hanne B Rasmussen, Annette E Langkilde and Bente Vestergaard. (2016) Monoclonal Antibodies Follow Distinct Aggregation Pathways During Production-Relevant Acidic Incubation and Neutralization Pharmaceutical Research 33(3):716-28.


Pernille Bøttger, Simon Glerup Pedersen, Bodil Gesslein, Nina Illarionova, Toke Jost Isaksen, Anders Heuck, Bettina Hjelm Clausen, Ernst-Martin Füchtbauer, Jan Bert Gramsbergen, Eli Gunnarson, Anita Aperia, Martin Lauritzen, Kate Lykke Lambertsen, Poul Nissen and Karin Lykke-Hartmann. (2016) Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model Scientific Reports 6(22047):e1002411.


Xianwei Zhang, Goran Bajic, Gregers R Andersen, Stig Hill Christiansen and Thomas Vorup-Jensen. (2016) The cationic peptide LL-37 binds Mac-1 (CD11b/CD18) with a low dissociation rate and promotes phagocytosis B B A - Proteins and Proteomics 24(3):351-352.


Stéphanie David-Bosne, Michael Voldsgaard Clausen, Hanne Poulsen, Jesper Vuust Møller, Poul Nissen and Marc le Maire. (2016) Reappraising the effects of artemisinin on the ATPase activity of PfATP6 and SERCA1a E255L expressed in Xenopus laevis oocytes Nature Structural and Molecular Biology 23(1):1-2.


Andreas Nørgård Larsen, Kasper Kildegaard Sørensen, Nicolai Tidemand Johansen, Anne Martel, Jacob Judas Kain Kirkensgaard, Knud Jørgen Jensen, Lise Arleth and Søren Roi Midtgaard. (2016) Dimeric peptides with three different linkers self-assemble with phospholipids to form peptide nanodiscs that stabilize membrane proteins Soft Matter 12(27):5937-5949.


Cédric Montigny, Joseph Lyons, Philippe Champeil, Poul Nissen and Guillaume Lenoir. (2016) On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport B B A - Molecular and Cell Biology of Lipids 1861:1-2.


Elena Papaleo, Giorgio Saladino, Matteo Lambrughi, Kresten Lindorff-Larsen, Francesco Luigi Gervasio and Ruth Nussinov. (2016) The role of protein loops and linkers in conformational dynamics and allostery Chemical Reviews 116(11):6391-6423.


Florian Hilbers, Wojciech Kopec, Toke Jost Isaksen, Thomas Hellesøe Holm, Karin Lykke-Hartmann, Poul Nissen, Himanshu Khandelia and Hanne Poulsen. (2016) Tuning of the Na,K-ATPase by the beta subunit. Scientific Reports 6(20442):282-293.


Haili Lin, Gregers Rom Andersen and Laure Yatime. (2016) Crystal structure of human S100A8 in complex with zinc and calcium B M C Structural Biology 16(3):351-352.


Henrik Kofoed Munch, Jesper Nygård, Niels Johan Christensen, Christian Engelbrekt, Mads Østergaard, Trine Porsgaard, Thomas Hoeg-Jensen, Jingdong Zhang, Lise Arleth, Peter Waaben Thulstrup and Knud Jørgen Jensen. (2016) Construction of insulin 18-mer nanoassemblies driven by coordination to Iron(II) and Zinc(II) ions at distinct sites Angewandte Chemie International Edition 55(7):2378-2381.


Jonas Lindholt Gregersen, Natalya Fedosova, Poul Nissen and Thomas Boesen. (2016) Reconstitution of Na,K-ATPase in Nanodiscs Methods in Molecular Biology 1377:403-409.


Katrine Østergaard Bugge, Elena Papaleo, Gitte Wolfsberg Haxholm, Jonathan T.S. Hopper, Carol V. Robinson, Johan Gotthardt Olsen, Kresten Lindorff-Larsen and Birthe Brandt Kragelund. (2016) A combined computational and structural model of the full-length human prolactin receptor Nature Communications 7(24):4424-4451.


Kristoffer Enøe Johansson, Nicolai Tidemand Johansen, Signe Christensen, Scott Horowitz, James C. A. Bardwell, Johan Gotthardt Olsen, Martin Willemoës, Kresten Lindorff-Larsen, Jesper Ferkinghoff-Borg, Thomas Wim Hamelryck and Jakob R. Winther. (2016) Computational redesign of thioredoxin is hypersensitive towards minor conformational changes in the backbone template Journal of Molecular Biology 428(21):4361-4377.


Lina Malinauskaite, Saida Said, Caglanur Sahin, Julie Grouleff, Azadeh Shahsavar, Henriette Bjerregaard, Pernille Rimmer Noer, Kasper Severinsen, Thomas Boesen, Birgit Schiøtt, Steffen Sinning and Poul Nissen. (2016) A Conserved Leucine Occupies the Empty Substrate Site of LeuT in the Na+-free Return State Nature Communications 7(20442):282-293.


Maher Mahmoud Kassem, Yong Wang, Wouter Krogh Boomsma and Kresten Lindorff-Larsen. (2016) Structure of the bacterial cytoskeleton protein bactofilin by NMR chemical shifts and sequence variation Biophysical Journal 110(11):2342-2348.


Mateusz Dyla, Jacob Andersen, Magnus Kjaergaard, Victoria Birkedal, Daniel S. Terry, Roger B. Altman, Scott Blanchard, Poul Nissen and Charlotte R Knudsen. (2016) Engineering a prototypic P-type ATPase Listeria Monocytogenes Ca(2+)-ATPase 1 for single-molecule FRET studies Bioconjugate Chemistry 27(9):2176-2187.


Matteo Lambrughi, Luca De Gioia, Francesco Luigi Gervasio, Kresten Lindorff-Larsen, Ruth Nussinov, Chiara Urani, Maurizio Bruschi and Elena Papaleo. (2016) DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions Nucleic Acids Research 44(19):9096-9109.


Michael Voldsgaard Clausen, Poul Nissen and Hanne Poulsen. (2016) The a4 isoform of the Na+ ,K+ -ATPase is tuned for changing extracellular environments The F E B S Journal (Online) 283(2):282-293.


Pengfei Tian, Kresten Lindorff-Larsen, Wouter Krogh Boomsma, Mogens Hogh Jensen and Daniel Erik Otzen. (2016) A Monte Carlo study of the early steps of functional amyloid formation P L o S One 11(1):2342-2348.


Thomas Hellesøe Holm, Toke Jost Isaksen, Simon Glerup Pedersen, Anders Heuck, Pernille Bøttger, Ernst-Martin Füchtbauer, Steen Torben Nedergaard, Jens Randel Nyengaard, Mogens Andreasen, Poul Nissen and Karin Lykke-Hartmann. (2016) Cognitive deficits caused by a disease-mutation in the a3 Na(+)/K(+)-ATPase isoform. Scientific Reports 6(31972):282-293.


Xiaolu Geng, Morten Jannik Bjerrum, Lise Arleth, Jeanette Otte and Richard Ipsen. (2016) Formation of nanotubes and gels at a broad pH range upon partial hydrolysis of bovine a-lactalbumin International Dairy Journal 52(7):72-81.


Yong Wang, Elena Papaleo and Kresten Lindorff-Larsen. (2016) Mapping transiently formed and sparsely populated conformations on a complex energy landscape eLife 5(24):4424-4451.

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